By train
Amtrak offers frequent services into Baltimore. The Penn Station is on Charles Street in Midtown—a considerable distance from the harbor area. However, a spur of the light rail system connects to the train station, and you can ride it to the convention center, three blocks from the harbor. Some Amtrak trains also stop at the BWI airport station which is a few miles south of the main Penn Station.
The MARC (http://www.mtamaryland.com/) train system provides inexpensive service between Baltimore and Washington, D.C. and from Washington to Frederick, Maryland and Martinsburg, West Virginia. It is, however, meant to be a commuter system, and runs only during work days/hours Monday - Friday. Check to be sure it is available when you need it. MARC trains operate through the Penn Station designated the "Penn line" on MARC schedules and through a station at Camden Yards the "Camden line", near the Inner Harbor.
By plane
The Baltimore-Washington International Airport IATA: BWI (http://www.bwiairport.com) is located a few miles outside of the city and is accessible by car or light rail. Shuttles connect BWI to an Amtrak train station just off the airport grounds.
There are non-stop flights to BWI from just about every major airport in the country, though some cities may be seasonal or only offer service certain days of the week. A full list can be found here: (http://www.bwiairport.com...).
BWI has a somewhat unique car rental system. Car rental facilities are located in a centralized facility located away from the airport. Airport shuttle buses must take travelers to and from the facility and it is advisable to plan an extra 10 to 15 minutes to get out of the airport. Also, if heading to Washington D.C., the signage from the airport's car rental facility is very poor and confusing, especially to Route 495. However, all roads ultimately lead to highway access in either direction North or South.
By bus
Buses are an affordable way to to get in to Baltimore if you are already in the Eastern Seaboard, especially if you are coming from New York or Philadelphia.